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  • The College of Medicine at University of Diyala hold a scientific symposium on the reverse vaccinology

The College of Medicine at University of Diyala hold a scientific symposium on the reverse vaccinology

  • Categories College News
  • Date April 25, 2023

The College of Medicine at University of Diyala hold a scientific symposium on the reverse vaccinology presented by Professor Dr. Areej Atiyah Hussein on the Hall 2 and organized by continuing education unit Therefore, the reverse vaccinology is one of the most important types of modern vaccines. The basic idea behind reverse vaccinology is that an entire pathogenic genome can be screened using bioinformatics approaches to find genes was used for the first time in 1995 by the American technologist John Venter, who worked on the genome of the free-living organism, the genomes of other microorganisms became more readily available throughout the end of the twentieth century.Attempts at reverse vaccinology first began with Meningococcus B (MenB). Meningococcus B caused over 50% of meningococcal meningitis.

The steps behind reverse vaccinology is that an entire pathogenic genome can be screened using bioinformatics approaches to find genes was used for the first time as the encoding area of a specific protein then introducing the plasmid into the certain bacteria to duplicate, the protein is purified and used in laboratory animals as an experimental vaccine after several weeks measuring the level of antibodies formed and the period required for their survival must be determine, finally the official approvals by the FDA Organization should be taken in order to use any new vaccine  through the World Health Organization. The symposium mention the advantages of this method as one of the very fast and easy methods compared to the traditional methods used in the production of vaccines such as live attenuated vaccine The downside is that only proteins can be targeted using this process. Whereas, conventional vaccinology approaches can find other biomolecule targets such as polysaccharides.

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