Ass.Prof.Dr.Qutaiba Ghanim Hussein|

Qutaiba Ghanim Hussein

Department of Pharmacology

College of Medicine

University of Diyala

Diyala

Iraq

Higher Education and Qualifications

Oct 2013 – Jan 2017:         School of Pharmacy and Pharmaceutical Sciences, College of Biomedical and Life Sciences, Cardiff University, United Kingdom

Feb 2008 – Feb 2010:        College of Pharmacy and Medical Technology, University of Petra, Amman, Jordan

Sep 2001 – July 2006:       College of Pharmacy, University of Baghdad, Baghdad, Iraq

Employment and Training History

June 2022 – present          Assistant Professor, College of Medicine, University of Diyala, Diyala, Iraq

Feb 2017 – May 2022         Lecturer,College of Medicine, University of Diyala, Diyala, Iraq.

July 2013 – Jan 2017:       PhD candidate, School of Pharmacy and Pharmaceutical Sciences, College of Biomedical and Life Sciences, Cardiff University, United Kingdom.

July 2010 – June 2013:     Assistant Lecturer and Coordinator of Department of Pharmacology, College of Medicine, University of Diyala, Diyala, Iraq.

Jan 2009 – June 2010:      Research Assistant, Central Research Lab (CRL), Jordanian Pharmaceutical Manufacturing Company Plc (JPM), Amman, Jordon.

Feb 2008 – Feb 2010         MSc candidate, College of Pharmacy and Medical Technology, University of Petra, Amman, Jordan

July 2006 – Jan 2008         Director, Al-yosor Pharmacy (Full-time), Diyala, Iraq.

Conference Presentations
  1. Qutuba G Karwi, Cory S Wagg, Tariq Altamimi, Gary D Lopschuk (2019). Mitochondrial protein kinase B (Akt) translocation mediates insulin-stimulated cardiac glucose oxidation. 23rd Annual Mazankowiski Cardiac Sciences Research Day, Edmonton, Canada. Poster.
  2. Qutuba G Karwi, Cory S Wagg, Tariq Altamimi, Gary D Lopschuk (2019). Mitochondrial protein kinase B (Akt) translocation mediates insulin-stimulated cardiac glucose oxidation. 6th Paediatrics Research Day, University of Alberta. Edmonton, Canada. Poster
  3. Qutuba G Karwi (2019). Targeting insulin resistance in heart failure. 4th EU-CARDIOPROTECTION COST Meeting, Kragujevac, Serbia. Invited Speaker
  4. Qutuba G. Karwi, Liyan Zhang, Cory S. Wagg, Wang Wang, Manoj Ghandi, Dung Thai, Hai Yan, John R. Ussher, Gavin Y. Oudit, Gary D. Lopaschuk (2018). Targeting the glucagon receptor improves cardiac function and enhances insulin sensitivity following a myocardial infarction. American Heart Association Scientific Sessions 2018, Chicago, Illinois, USA. Poster
  5. Qutuba G. Karwi, Liyan Zhang, Abhishek Gupta, Arata Fukushima, Vaibhav Patel, Osama Abo Alrob, Tariq Altamimi, Cory S. Wagg, Raj S. Padwal, David E. Johnstone, Arya M. Sharma, Gavin Y. Oudit, Gary D. Lopaschuk (2018). Caloric restriction limits fatty acid oxidation and improves cardiac function in heart failure associated with obesity. 22nd Annual Mazankowiski Cardiac Sciences Research Day, Edmonton, Canada. Oral presentation
  6. Qutuba G. Karwi, Liyan Zhang, Abhishek Gupta, Arata Fukushima, Vaibhav Patel, Osama Abo Alrob, Tariq Altamimi, Cory S. Wagg, Raj S. Padwal, David E. Johnstone, Arya M. Sharma, Gavin Y. Oudit, Gary D. Lopaschuk (2018). Caloric restriction limits fatty acid oxidation and improves cardiac function in heart failure associated with obesity. 5th Paediatrics Research Day, University of Alberta. Edmonton, Canada. Poster
  7. Qutuba G. Karwi, Liyan Zhang, Abhishek Gupta, Arata Fukushima, Vaibhav Patel, Osama Abo Alrob, Tariq Altamimi, Cory S. Wagg, Raj S. Padwal, David E. Johnstone, Arya M. Sharma, Gavin Y. Oudit, Gary D. Lopaschuk (2018). Caloric restriction limits fatty acid oxidation and improves cardiac function in heart failure associated with obesity. 37th annual conference of the north American Section of the international Society for Heart Research. Halifax, Canada. Oral presentation.
  8. Qutuba Karwi, Matt Whiteman, Mark Wood, Gary Baxter (2017). The effect of hydrogen sulfide (H2S) on reperfusion-inducedventricular arrhythmias. 34th meeting of the ISHR-ES, Hamburg, Germany, Poster.
  9. Qutuba G. Karwi, J.S. Bice, G.F. Baxter (2017). Pre- and post-conditioning with hydrogen sulfide in vivo: a systematic review and meta-analysis. 34th meeting of the ISHR-ES, Hamburg, Germany, Poster.
  10. Qutuba Karwi, Matt Whiteman, Mark Wood, Gary Baxter (2017). Postconditioning with H2S donors: effect on reperfusion-induced ventricular arrhythmias. 36th meeting of the ISHR-NAS New Orleans, USA. Poster
  11. Qutuba Karwi, Matt Whiteman, Mark Wood, Gary Baxter (2016). Molecular mechanism of H2S induced cardioprotection. 4th International Conference on the Biology of Hydrogen Sulfide. Naples, Italy, Oral presentation
  12. Qutuba Karwi, Matt Whiteman, Mark Wood, Gary Baxter (2016). Postconditioning with H2S: Molecular Pharmacology. Ischemic Conditioning And Targeting Reperfusion Injury: A 30 Year Voyage Of Discovery. Barcelona, Spain, Poster
  13. Qutuba Karwi, Matt Whiteman, Mark Wood, Gary Baxter (2016). Postconditioning with mitochondrial-targeting hydrogen sulfide donor (AP39). XXII ISHR World Congress, Buenos Aires, Argentina. Oral presentation
  14. Qutuba Karwi, Matt Whiteman, Mark Wood, Gary Baxter (2015). Infarct limitation by GYY4137 at reperfusion, a slow-releasing hydrogen sulfide donor, in the rat in vivo. Pharmacology 2015, London, United Kingdom. Oral presentation
  15. Qutuba Karwi, Matt Whiteman, Mark Wood, Gary Baxter (2015). Infarct Limitation by GYY4137 at reperfusion, a slow-releasing hydrogen sulfide donor, is PI3K/Akt-dependant with partial dependency on endothelial NO in the rat in vivo. 33rd Annual Meeting of the European Section of the ISHR, Bordeaux, France. Oral presentation and poster.
Book chapters
  1.  Nidal A Qinna, Qutuba G Karwi, Nawzat Al-Jbour, Mayyas A Al-Remawi, Tawfiq M Alhussainy, Khaldoun A Al-So’ud, Mahmoud M H Al Omari, Adnan A Badwan (2018). Insulin Preparations. Advances in Marine Chitin and Chitosan, 340.
Peer-reviewed published papers
  1. , Liyan Zhang, Tariq R. Altamimi, Cory S. Wagg, Vaibhav Patel, Golam M. Uddin, Alice R. Joerg, Raj S. Padwal, David E. Johnstone, Arya Sharma, Gavin Y. Oudit, Gary D. Lopaschuk (2019). Weight loss enhances cardiac energy metabolism and function in heart failure associated with obesity. Diabetes Obesity and Metabolism, 21(8):1944-1955. doi: 10.1111/dom.13762.
  2. Alice R Joerg, Gary D Lopaschuk (2019). Allosteric, transcriptional and post-translational control of mitochondrial energy metabolism. Biochemcial Journal, 476(12):1695-1712. doi: 10.1042/BCJ20180617.
  3. , Zhang L, Wagg CS, Wang W, Ghandi M, Thai D, Yan H, Ussher JR, Oudit GY, Lopaschuk GD (2019). Targeting the glucagon receptor improves cardiac function and enhances insulin sensitivity following a myocardial infarction. Cardiovascular Diabetology, 9;18(1):1.
  4. , GM Uddin, KL Ho, GD Lopaschuk (2018). Energy metabolic flexibility in the failing heart. Frontiers in Cardiovascular Medicine, 5:68.
  5. , J.S. Bice, G.F. Baxter (2018). Pre- and post-conditioning the heart with hydrogen sulfide (H2S) against ischemia/reperfusion injury in vivo: a systematic review and meta-analysis. Basic research in Cardiology, 113:6.
  • Karwi, Q. G., Bornbaum, J., Boengler. K., Torregrossa. R., Whiteman, M., Wood, M., Schulz, R., Baxter, G. F. (2017). AP39, a mitochondria-targeting hydrogen sulfide (H2S) donor, protects against myocardial reperfusion injury independently of salvage kinase signalling. British Journal of Pharmacology, 174 (4), 287-301.
  • Karwi, Q. G., Whiteman, M., Wood, M. E., Torregrossa, R. & Baxter, G. F. (2016). Pharmacological postconditioning against myocardial infarction with a slow-releasing hydrogen sulfide donor, GYY4137. Pharmacological Research, 111, 442-451.
  • Qinna, N. A., Karwi, Q. G., Al-jbour, N., Al-remawi, M. A., Alhussainy, T. M., Al-so’ud, K. A., Al omeri, M. M. & Badwan, A. A. (2015). Influence of molecular weight and degree of deacetylation of low molecular weight chitosan on the bioactivity of oral insulin preparations. Marine Drugs, 13, 1710-1725.
  • R Shaima’a, Qutuba G Karwi, Anfal Shakir Motib (2014). Antibacterial activity of garlic extract on bacteria isolated from teeth. Diyala Journal for Pure Science 10, 50-58.
  • Salwa Sh Abdulwahid, Sana A Abdulwahab, Qutuba G Karwi (2013). Correlation between herpes simplex virus type-1 incidence and mental disorders. American Journal of research Communication, 1(5), 9-17.
  • Qutuba G Karwi (2013). Assess the Common Sexually Transmitted Diseases and Cost-effectiveness Estimation. American Journal of research Communicationm, 1(6), 18-26.
  • Tariq Altamimi; Su Gao, Qutuba G Karwi, Arata Fukushima, Sonia Rawat, Cory S Wagg; Liyan Zhang, Gary D Lopaschuk (2019). Adropin Regulates Cardiac Energy Metabolism and Improves Cardiac Function and Efficiency. Metabolism: Clinical and Experimental (Under final revision).
  • Golam M. Uddin, Liyan Zhang, Saumya Shah, Arata Fukushima, Cory S. Wagg, Keshav Gopal, Rami Al Batran, Simran Pherwani, Kim L. Ho, Jamie Boisvenue, Qutuba G. Karwi, Tariq Altamimi, David S. Wishart, Jason R.B. Dyck, John R. Ussher, Gavin Y. Oudit, Gary D. Lopaschuk (2019). Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure. Journal of Clinical Investigation (Under revision).

Published Abstract

  1. Karwi QG, Zhang L, Wagg CS, Wang W, Ghandi M, Thai D, Yan H, Ussher JR, Oudit GY, Lopaschuk GD (2019). Targeting the glucagon receptor improves cardiac function and enhances insulin sensitivity following a myocardial infarction. Circulation Research, 123(12), E73-E73.
  2. Matthew Whiteman, Qutuba G Karwi, Mark E Wood, Gary F Baxter (2017). Mitochondria-targeted hydrogen sulfide (H2S), but not untargeted H2S, reverses ventricular arrhythmia at reperfusion. Free radical Biology and Medicine, 112, 124-125.
  3. Karwi QG, Whiteman M, Wood M, Baxter G (2017). Postconditioning with H2S donors: effect on reperfusion-induced ventricular arrhythmias. Journal of Molecular and Cellular Cardiology, 112, 142-143.
  4. Q.G. Karwi, M. Whiteman, M. Wood, G. Baxter (2017). The effect of hydrogen sulfide (H2S) on reperfusion-induced ventricular arrhythmias.Journal of Molecular and Cellular Cardiology, 109, S1-S62.
  5. Q.G. Karwi, J.S. Bice, G.F. Baxter (2017). Pre- and post-conditioning with hydrogen sulfide in vivo: a systematic review andmeta-analysis. Journal of Molecular and Cellular Cardiology, 109, S1-S62.
  6. Qutuba Karwi (2016). Molecular mechanism of H2S-induced cardioprotection. http://h2s2016naples.avec-eventi.com/images/pdf/abstract_book.pdf
  7. Q. Karwi, M. Whiteman, M. Wood, G. Baxter (2016). Postconditioning with H2S: molecular pharmacology. Journal of Molecular and Cellular Cardiology, 97, S1-S18.
  8. Qutuba Karwi, Matt Whiteman, Mark Wood, Gary Baxter (2016). Postconditioning with mitochondrial-targeting hydrogen sulfide donor (AP39). Journal of Molecular and Cellular Cardiology, 98, S1-S85.
  9. Karwi, Q. G.; Whiteman, M.; Wood, M.; Ford, W.; Baxter, G. F. (2015). Infarct limitation by GYY4137 at reperfusion, a slow-releasing hydrogen sulfide donor, in the rat in vivo. E-journal of British Pharmacological Society. (http://www.pa2online.org/abstract/abstract.jsp?abid=32759&author=karwi&cat=-1&period=61).
  10. Karwi, Q. G.; Whiteman, M.; Wood, M.; Ford, W.; Baxter, G. F. (2015). Infarct limitation by GYY4137 at reperfusion, a slow-releasing hydrogen sulfide donor, is PI3K/Akt-dependant with partial dependency on endothelial NO in the rat in vivo. Journal of Molecular and Cellular Cardiology 86, S1-S78.
Professional Membership
  • American Heart Association (AHA), member (000243796582)
  • International Society of Heart Research-North American Section (ISHR-NAS), member.
  • British Society of Cardiovascular Research (BSCR), member
  • British Pharmacological Society (BPS), member.
  • British Journal of Pharmacology, reviewer.
  • Science, Technology, Engineering and Mathematics (STEM) ambassador.
  • Elsevier Advisory Panel, member.
  • The Science Advisory Board, member.